New Alzheimer’s Breakthrough Could Help Millions With This New Clinical Trial
Alzheimer’s is one of the most devastating diseases on the face of the planet. It takes a family member you love, and it slowly strips away their memories and ability t0 recognize people they’ve known for decades. It’s so bad that you can talk to family who’ve known someone with the disease, and they will tell you that after years of suffering, they’re actually relieved that the loved one has passed because of the torture it has put on them.
Thanks to breakthrough drug, Alzheimer’s may be on its way out. Scientists from the Technical University of Munich has published a new paper showing that a BACE inhibitor drug can reduce the amount of amyloid beta in the brains of mice. It can then be able to restore normal function of nerve cells that can significantly improve memory.
A little bit of an explanation on all those terms up there: Amyloid beta is a protein that is believed to be the major cause of Alzheimer’s. A BACE inhibitor is various substances that reduce the production of amyloid beta.
So far, no drug on the market can stop the menace that is Alzheimer’s, but this may be a path forward on further understanding its devastating effect on around 50 million people around the world.
The study, led by Dr. Aylin Keskin, tested the substance on a mouse brain model with Alzheimer’s. The mice that were used in the study were setup to accumulate a mass amount of the amyloid beta, which becomes the plaque that causes the disease. They were then fed the beta secretase inhibitor for up to eight weeks. The study shows that the amount of amyloid beta in the brain normalized, and looked similar to those of healthy mice.
When the tests were done, it was shown that the memory of the tested mice could remember various tasks and locations in mazes as fast as mice that were not subjected to the tests.
“What really impressed and amazed us was the reversibility of the symptoms. Before the treatment, the mice had a marked clinical picture with amyloid beta plaques in their brain. Nevertheless, the substance was able to restore important brain functions and abilities,” said Dr. Keskin of the tests.
Since the trials were so successful, plans are in place to start a large-scale clinical trial on nearly 1,000 people to try to BACE inhibitor drug. I think we all have our fingers crossed for some good to come out of this.
A further explanation on the science it all:
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Jeff Sorensen is an author, writer and occasional comedian living in Detroit, Michigan. You can look for more of his work on The Huffington Post, UPROXX, BGR and by just looking up his name.